Cells are known to differentiate in response to specific biochemical cues. It is unclear though if mechanical cues can instruct cells to differentiate during embryonic development. In collaboration with the group of Jerome Gros at the Institut Pasteur (Paris), we are mapping the spatial variations in endogenous cellular forces driving vertebrate limb formation while simultaneously monitoring cell type specification. Our goal is to determine if the endogenous forces drive chondrogenic differentiation in developing vertebrate limbs.